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Public trial

Application of Telecare technologies in patients with Temporomandibular Disorders and Bruxism

Date of registration: 06/30/2025 ^(mm/dd/yyyy)
Last approval date : 06/30/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Comparing two doses of Botulinum toxin A in the treatment of urinary symptoms

Date of registration: 01/25/2017 ^(mm/dd/yyyy)
Last approval date : 06/30/2025 ^(mm/dd/yyyy)
Last revision: 2

Study type:

Interventional

Implementation of a care program on falls prevention in older adults at high risk of falls

Date of registration: 06/30/2025 ^(mm/dd/yyyy)
Last approval date : 06/30/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Evaluation of the Implantation of a biomaterial in the form of a Biocellulose with Strontium Apatite membrane for preservation of the dental supporting bone margin: a randomized, double-masked study with patients

Date of registration: 06/30/2025 ^(mm/dd/yyyy)
Last approval date : 06/30/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

The effect of Stepping Training with Visual Stimulation on older adults

Date of registration: 06/28/2025 ^(mm/dd/yyyy)
Last approval date : 06/28/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Study on the impact of educational activities using the dietary guidelines on the eating habits of high school students

Date of registration: 06/28/2025 ^(mm/dd/yyyy)
Last approval date : 06/28/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

THYRI Project: Two-plane uterine suture to decrease myometrial dehiscence in the cesarean site.

Date of registration: 06/28/2025 ^(mm/dd/yyyy)
Last approval date : 06/28/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Analysis of the Oral Environment in patients treated with Laser Therapy for Oral Mucositis

Date of registration: 06/28/2025 ^(mm/dd/yyyy)
Last approval date : 06/28/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Performance evaluation of peri-implant Mucositis treatment using Subgingival Polishing with Erythritol Powder

Date of registration: 06/27/2025 ^(mm/dd/yyyy)
Last approval date : 06/27/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Physiotherapeutic Follow-up of Patients with Chronic Low Back Pain: Multidimensional Assessment and Use of Data from an Extension Project

Date of registration: 06/27/2025 ^(mm/dd/yyyy)
Last approval date : 06/27/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Observational

Awareness Raising Interventions in Schools: Education on aging and brain health for teachers

Date of registration: 06/26/2025 ^(mm/dd/yyyy)
Last approval date : 06/26/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Effects of a maintenance program with different supervision frequencies in individuals with chronic respiratory disease

Date of registration: 06/26/2025 ^(mm/dd/yyyy)
Last approval date : 06/26/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Comparison of the effects of the Invisalign Palatal Expander (IPE) and the Hyrax Expander in the treatment of narrow maxilla

Date of registration: 06/26/2025 ^(mm/dd/yyyy)
Last approval date : 06/26/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Radiotherapy dose mapping for head and neck Cancer associated with treatment toxicities

Date of registration: 06/26/2025 ^(mm/dd/yyyy)
Last approval date : 06/26/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Observational

Benefits of Nutrition and Physical Activity for the health of people with Kidney Issues

Date of registration: 06/26/2025 ^(mm/dd/yyyy)
Last approval date : 06/26/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Observational

The effect of therapeutic ultrasound treatment combined with intense physical exercise on reducing belly fat in obese patients

Date of registration: 02/08/2023 ^(mm/dd/yyyy)
Last approval date : 06/26/2025 ^(mm/dd/yyyy)
Last revision: 4

Study type:

Interventional

Adaptation, usability and initial results of a mindfulness program to support people in the search for meaning in life in a study with comparison groups

Date of registration: 06/25/2025 ^(mm/dd/yyyy)
Last approval date : 06/25/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Effectiveness and safety evaluate of Covid-19 vaccines by the National Immunization Program: a multicenter cohort study in brazilian healthcare workers

Date of registration: 06/24/2025 ^(mm/dd/yyyy)
Last approval date : 06/24/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Observational

Improving oral care in intensive care units patients: evaluation of the impact on hospital stay and survival rates: a clinical study

Date of registration: 06/19/2025 ^(mm/dd/yyyy)
Last approval date : 06/19/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Effect of Water Exercise on the heart of postmenopausal women with high blood pressure

Date of registration: 06/19/2025 ^(mm/dd/yyyy)
Last approval date : 06/19/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

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News

01/12/2026

What Delays Colorectal Cancer Diagnosis in Brazil

01/12/2026 | Daniela Barros | Medscape

https://portugues.medscape.com/viewarticle/atrasa-diagn%C3%B3stico-cncer-colorretal-brasil-2026a10000wc?form=fpf

In colorectal cancer, the moment of diagnosis is a silent milestone that separates patients who can still follow a predominantly curative trajectory from those who begin treatment in a scenario of greater clinical complexity, with high costs and a lower probability of prolonged disease control. This is the central message of the study "Colorectal Cancer in Brazil: The Invisible Challenge of Diagnosis," coordinated by the Cancer Foundation, which analyzed 177,575 cases of this type of tumor registered in Brazil between 2013 and 2022.

The majority of patients were ≥ 50 years old (85.9%) and almost half resided in the Southeast region (49.4%), reinforcing that the problem is not limited to areas with fewer resources, but also appears where there is a greater concentration of services and volume of care. More than 60% of cases with reported staging were diagnosed in stages III and IV, when the tumor has already spread beyond the intestine or has become widespread. "This is a catastrophe," states the oncological surgeon Dr. Luiz Augusto Maltoni, executive director of the Cancer Foundation.

“Diagnosis at an advanced stage completely changes the course of care: it increases the need to combine different treatment modalities—such as surgery, chemotherapy, and radiotherapy—raises the risk of complications, and imposes a high cost not only on the healthcare system but also on the patient and their family,” she says.

In stage IV, when the disease is already metastatic, the impact is even more evident, with a lower chance of cure and a worse overall prognosis. In early stages, the chance of cure can be greater than…

01/12/2026

Mayo Clinic Q&A: What does it mean to be in a cancer clinical trial?

01/12/2026 | Justin Gottlieb | Mayo Clinic

https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-qa-what-does-it-mean-to-be-in-a-cancer-clinical-trial/

DEAR MAYO CLINIC: Our daughter was recently diagnosed with cancer. She's interested in participating in a clinical trial but doesn't really know what that means or how to get involved. Can you help?

ANSWER: A cancer diagnosis can feel overwhelming and often comes with a long list of decisions to make.

Many people are surprised to learn that clinical trials aren't just for people who have run out of standard treatment options, but are an important part of cancer care at every stage and most aspects of diagnosis and treatment. They help physicians study new and better ways to diagnose, treat and improve the quality of life for people. They also give patients access to promising treatments that they might not otherwise receive.

What happens in a cancer clinical trial?
During a clinical trial, participants may receive specific interventions or potentially the standard treatment. Researchers measure how safe and effective the interventions are and usually compare them to standard treatments. These may include:

New cancer drugs or drug combinations.
New medical procedures or devices.
New surgical techniques.
New ways to use existing treatments.
Lifestyle or behavioral approaches.

One of the biggest misconceptions is that joining a trial means you might not receive treatment or be given a placebo. Most clinical trials compare a new treatment with the current standard of care.

Who's eligible for a trial?
Your daughter’s care team is the best starting point. Feel free to ask if she is a candidate…

01/12/2026

Why So Many Head and Neck Cancer Clinical Trials Fail

01/12/2026 | by/Staff Writer | Miller School of Medicine

https://news.med.miami.edu/why-so-many-head-and-neck-cancer-trials-fail/

Head and neck cancer ranks as the seventh most common cancer worldwide, and its incidence continues to rise. In the United States alone, 2025 projections estimate more than 72,000 new cases and 16,000 deaths. More than 90% of these cancers are head and neck squamous cell carcinomas, which originate in the mucosal lining of the oral cavity, pharynx and larynx.

While immunotherapy and precision chemoradiation have improved outcomes for some patients, survival rates for recurrent or metastatic head and neck squamous cell carcinomas remain dismal. Clinical trials are essential to finding better treatments, but many fail before completion.

A Troubling Trend for Head and Neck Cancer Clinical Trials
Researchers from Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, and collaborators analyzed 692 clinical trials launched between 2000 and 2024.

Alex Reznik, an M.D./Ph.D. student at the Miller School and co-author of the study, described the study as “a retrospective query of head and neck cancer clinical trials in which we compared trial characteristics between failed clinical trials and completed clinical trials.”

The study included 346 studies that ended early, either terminated or were withdrawn. The leading culprits?

• Strategic decisions by sponsors, often unrelated to safety or efficacy (29.5%)

• Poor patient recruitment (26%)

Early-phase trials and those testing immunotherapies or targeted therapies were more likely to fail because of sponsor-driven decisions. Later-phase trials investigating chemotherapy, radiation or combination treatments struggled with enrollment.

…

01/09/2026

UFPel recruits volunteers for dengue vaccine study

01/09/2026 | Frederico Feijó | GZH Zona Sul

https://gauchazh.clicrbs.com.br/zona-sul/saude/noticia/2026/01/ufpel-recruta-voluntarios-para-estudo-de-vacina-contra-a-dengue-cmk70eyhp01xc011h0i5uj7nv.html

The study will be conducted at the Clinical Research Center of the Teaching Hospital and is seeking participants between the ages of 40 and 79.

The Teaching Hospital of the Federal University of Pelotas (HE-UFPel) has begun recruiting volunteers for a clinical study of a dengue vaccine, which will be developed at the institution's Clinical Research Center. The initiative is part of efforts to support the Unified Health System (SUS), with a focus on disease prevention and strengthening scientific production.

The study, identified as DEN-04, aims to evaluate a new dengue vaccine and is recruiting people between the ages of 40 and 79. Participation is voluntary and intended for residents of the region interested in contributing to the advancement of science and public health.

To participate, interested parties must complete a clinical study interest form. Based on this registration, the Clinical Research Center team forms a database of potential volunteers and conducts an initial screening, with interviews and consultations, to verify that candidates meet the criteria defined in the protocols. After this stage, selected participants are contacted to receive guidance on the next phases of the research.

In addition to DEN-04, HE-UFPel plans to start a new clinical study in the coming months. The project, called Codenchik, will evaluate the co-administration of vaccines against dengue and chikungunya and is expected to recruit volunteers between the ages of 18 and 59.

For Rosiane Mastelari, head of the Research Management…

01/09/2026

Butantan calls for elderly volunteers in Pernambuco to participate in a study of a new flu vaccine for the Brazilian Unified Health System (SUS)

01/09/2026 | Cinthya Leite | JC PE

https://jc.uol.com.br/colunas/saude-e-bem-estar/2026/01/09/butantan-convoca-em-pernambuco-idosos-voluntarios-para-estudo-de-nova-vacina-contra-gripe-voltada-ao-sus.html

National study compares new Butantan vaccine with high-concentration vaccine used in private clinics, with potential direct impact on the Brazilian public health system (SUS)

Aging brings natural changes to the body, and one of the most important occurs in the immune system. Over the years, the body's defenses become less efficient, a process known as immunosenescence. It is a condition that, among other things, reduces the response to traditional vaccines and increases the risk of complications caused by the flu.

Given this scenario, there is a need for more specific and potent protection against the influenza virus designed for the elderly. With this goal in mind, the Butantan Institute has developed a new flu vaccine aimed exclusively at people aged 60 and over. Next Monday (12), in Recife, the recruitment of volunteers for the final phase of clinical trials will begin.

Pernambuco is among the states participating in the study, through the Plátano Clinical Research Center, which has already begun to register interested parties.

Currently, more potent flu vaccines for the elderly are only available in the private sector, which restricts access for a large part of the population. The study with the new Butantan vaccine seeks to change this reality.

The research will assess whether Butantan's new adjuvanted vaccine is equivalent to or superior to the high-concentration vaccine marketed in private clinics. If the results confirm its effectiveness, the impact could be direct on public health.

…