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Public trial

Medicinal plant spray to reduce tooth sensitivity after In-office Tooth Whitening

Date of registration: 05/05/2025 ^(mm/dd/yyyy)
Last approval date : 05/05/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Change in grip strength induced by overflow contralateral to hip flexion

Date of registration: 05/03/2025 ^(mm/dd/yyyy)
Last approval date : 05/03/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

The effects of non-invasive cerebral electrical stimulation associated with cardiorespiratory training on blood pressure parameters, respiratory rate, functional capacity and muscle strength in sedentary individuals

Date of registration: 04/30/2025 ^(mm/dd/yyyy)
Last approval date : 04/30/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Evaluation of Caffeine and Sodium Bicarbonate in Athletes

Date of registration: 04/30/2025 ^(mm/dd/yyyy)
Last approval date : 04/30/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Use of Calendula and Chamomile in the prevention and treatment of Skin Irritation caused by radiotherapy in patients with head and neck cancer: clinical study

Date of registration: 04/30/2025 ^(mm/dd/yyyy)
Last approval date : 04/30/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Treatment of joint pain after Chikungunya

Date of registration: 04/30/2025 ^(mm/dd/yyyy)
Last approval date : 04/30/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Auriculotherapy for stress and quality of students

Date of registration: 04/30/2025 ^(mm/dd/yyyy)
Last approval date : 04/30/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Innovation in health: analysis of physiological signals for the prevention and monitoring of Cardiovascular and Metabolic Diseases

Date of registration: 04/30/2025 ^(mm/dd/yyyy)
Last approval date : 04/30/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Observational

Effects of Bodybuilding Exercise performed at night on sleep in adults

Date of registration: 04/30/2025 ^(mm/dd/yyyy)
Last approval date : 04/30/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

The Influence of the Pharmacist on the Treatment of Patients with Heart Failure: a Randomized Clinical Trial

Date of registration: 04/29/2025 ^(mm/dd/yyyy)
Last approval date : 04/29/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Effect of Polydextrose consumption on the composition of intestinal bacteria and blood sugar control in patients with Gestational Diabetes Mellitus

Date of registration: 04/29/2025 ^(mm/dd/yyyy)
Last approval date : 04/29/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Effects of an Educational Intervention to change the lifestyle of people at risk for diabetes

Date of registration: 04/29/2025 ^(mm/dd/yyyy)
Last approval date : 04/29/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Efficacy of Light Therapy in Temporomandibular Dysfunction in people with different skin tones: a clinical study

Date of registration: 04/29/2025 ^(mm/dd/yyyy)
Last approval date : 04/29/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Low-intensity Exercises during Chemotherapy infusion in women with Breast Cancer

Date of registration: 04/29/2025 ^(mm/dd/yyyy)
Last approval date : 04/29/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Therapeutic effects of jaboticaba (Plinia jaboticaba) peel on ulcerative colitis

Date of registration: 04/28/2025 ^(mm/dd/yyyy)
Last approval date : 04/28/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Research using technology to promote healthy eating among teenagers

Date of registration: 04/28/2025 ^(mm/dd/yyyy)
Last approval date : 04/28/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

How different Exercise intensities affect pain, mobility, and quality of life in people with Hip Osteoarthritis: a clinical study

Date of registration: 04/28/2025 ^(mm/dd/yyyy)
Last approval date : 04/28/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Breastfeeding and Buzzy® in reducing pain during childhood vaccination: randomized clinical trial

Date of registration: 04/28/2025 ^(mm/dd/yyyy)
Last approval date : 04/28/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Comparison of the immediate effects of transcranial electrical stimulation with different current patterns on cortical metrics among healthy individuals, with ADHD and depressive symptoms

Date of registration: 04/28/2025 ^(mm/dd/yyyy)
Last approval date : 04/28/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Effects of edible mushroom supplementation on Hypertension, heart function and gut: a clinical study

Date of registration: 04/28/2025 ^(mm/dd/yyyy)
Last approval date : 04/28/2025 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

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News

01/12/2026

What Delays Colorectal Cancer Diagnosis in Brazil

01/12/2026 | Daniela Barros | Medscape

https://portugues.medscape.com/viewarticle/atrasa-diagn%C3%B3stico-cncer-colorretal-brasil-2026a10000wc?form=fpf

In colorectal cancer, the moment of diagnosis is a silent milestone that separates patients who can still follow a predominantly curative trajectory from those who begin treatment in a scenario of greater clinical complexity, with high costs and a lower probability of prolonged disease control. This is the central message of the study "Colorectal Cancer in Brazil: The Invisible Challenge of Diagnosis," coordinated by the Cancer Foundation, which analyzed 177,575 cases of this type of tumor registered in Brazil between 2013 and 2022.

The majority of patients were ≥ 50 years old (85.9%) and almost half resided in the Southeast region (49.4%), reinforcing that the problem is not limited to areas with fewer resources, but also appears where there is a greater concentration of services and volume of care. More than 60% of cases with reported staging were diagnosed in stages III and IV, when the tumor has already spread beyond the intestine or has become widespread. "This is a catastrophe," states the oncological surgeon Dr. Luiz Augusto Maltoni, executive director of the Cancer Foundation.

“Diagnosis at an advanced stage completely changes the course of care: it increases the need to combine different treatment modalities—such as surgery, chemotherapy, and radiotherapy—raises the risk of complications, and imposes a high cost not only on the healthcare system but also on the patient and their family,” she says.

In stage IV, when the disease is already metastatic, the impact is even more evident, with a lower chance of cure and a worse overall prognosis. In early stages, the chance of cure can be greater than…

01/12/2026

Mayo Clinic Q&A: What does it mean to be in a cancer clinical trial?

01/12/2026 | Justin Gottlieb | Mayo Clinic

https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-qa-what-does-it-mean-to-be-in-a-cancer-clinical-trial/

DEAR MAYO CLINIC: Our daughter was recently diagnosed with cancer. She's interested in participating in a clinical trial but doesn't really know what that means or how to get involved. Can you help?

ANSWER: A cancer diagnosis can feel overwhelming and often comes with a long list of decisions to make.

Many people are surprised to learn that clinical trials aren't just for people who have run out of standard treatment options, but are an important part of cancer care at every stage and most aspects of diagnosis and treatment. They help physicians study new and better ways to diagnose, treat and improve the quality of life for people. They also give patients access to promising treatments that they might not otherwise receive.

What happens in a cancer clinical trial?
During a clinical trial, participants may receive specific interventions or potentially the standard treatment. Researchers measure how safe and effective the interventions are and usually compare them to standard treatments. These may include:

New cancer drugs or drug combinations.
New medical procedures or devices.
New surgical techniques.
New ways to use existing treatments.
Lifestyle or behavioral approaches.

One of the biggest misconceptions is that joining a trial means you might not receive treatment or be given a placebo. Most clinical trials compare a new treatment with the current standard of care.

Who's eligible for a trial?
Your daughter’s care team is the best starting point. Feel free to ask if she is a candidate…

01/12/2026

Why So Many Head and Neck Cancer Clinical Trials Fail

01/12/2026 | by/Staff Writer | Miller School of Medicine

https://news.med.miami.edu/why-so-many-head-and-neck-cancer-trials-fail/

Head and neck cancer ranks as the seventh most common cancer worldwide, and its incidence continues to rise. In the United States alone, 2025 projections estimate more than 72,000 new cases and 16,000 deaths. More than 90% of these cancers are head and neck squamous cell carcinomas, which originate in the mucosal lining of the oral cavity, pharynx and larynx.

While immunotherapy and precision chemoradiation have improved outcomes for some patients, survival rates for recurrent or metastatic head and neck squamous cell carcinomas remain dismal. Clinical trials are essential to finding better treatments, but many fail before completion.

A Troubling Trend for Head and Neck Cancer Clinical Trials
Researchers from Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, and collaborators analyzed 692 clinical trials launched between 2000 and 2024.

Alex Reznik, an M.D./Ph.D. student at the Miller School and co-author of the study, described the study as “a retrospective query of head and neck cancer clinical trials in which we compared trial characteristics between failed clinical trials and completed clinical trials.”

The study included 346 studies that ended early, either terminated or were withdrawn. The leading culprits?

• Strategic decisions by sponsors, often unrelated to safety or efficacy (29.5%)

• Poor patient recruitment (26%)

Early-phase trials and those testing immunotherapies or targeted therapies were more likely to fail because of sponsor-driven decisions. Later-phase trials investigating chemotherapy, radiation or combination treatments struggled with enrollment.

…

01/09/2026

UFPel recruits volunteers for dengue vaccine study

01/09/2026 | Frederico Feijó | GZH Zona Sul

https://gauchazh.clicrbs.com.br/zona-sul/saude/noticia/2026/01/ufpel-recruta-voluntarios-para-estudo-de-vacina-contra-a-dengue-cmk70eyhp01xc011h0i5uj7nv.html

The study will be conducted at the Clinical Research Center of the Teaching Hospital and is seeking participants between the ages of 40 and 79.

The Teaching Hospital of the Federal University of Pelotas (HE-UFPel) has begun recruiting volunteers for a clinical study of a dengue vaccine, which will be developed at the institution's Clinical Research Center. The initiative is part of efforts to support the Unified Health System (SUS), with a focus on disease prevention and strengthening scientific production.

The study, identified as DEN-04, aims to evaluate a new dengue vaccine and is recruiting people between the ages of 40 and 79. Participation is voluntary and intended for residents of the region interested in contributing to the advancement of science and public health.

To participate, interested parties must complete a clinical study interest form. Based on this registration, the Clinical Research Center team forms a database of potential volunteers and conducts an initial screening, with interviews and consultations, to verify that candidates meet the criteria defined in the protocols. After this stage, selected participants are contacted to receive guidance on the next phases of the research.

In addition to DEN-04, HE-UFPel plans to start a new clinical study in the coming months. The project, called Codenchik, will evaluate the co-administration of vaccines against dengue and chikungunya and is expected to recruit volunteers between the ages of 18 and 59.

For Rosiane Mastelari, head of the Research Management…

01/09/2026

Butantan calls for elderly volunteers in Pernambuco to participate in a study of a new flu vaccine for the Brazilian Unified Health System (SUS)

01/09/2026 | Cinthya Leite | JC PE

https://jc.uol.com.br/colunas/saude-e-bem-estar/2026/01/09/butantan-convoca-em-pernambuco-idosos-voluntarios-para-estudo-de-nova-vacina-contra-gripe-voltada-ao-sus.html

National study compares new Butantan vaccine with high-concentration vaccine used in private clinics, with potential direct impact on the Brazilian public health system (SUS)

Aging brings natural changes to the body, and one of the most important occurs in the immune system. Over the years, the body's defenses become less efficient, a process known as immunosenescence. It is a condition that, among other things, reduces the response to traditional vaccines and increases the risk of complications caused by the flu.

Given this scenario, there is a need for more specific and potent protection against the influenza virus designed for the elderly. With this goal in mind, the Butantan Institute has developed a new flu vaccine aimed exclusively at people aged 60 and over. Next Monday (12), in Recife, the recruitment of volunteers for the final phase of clinical trials will begin.

Pernambuco is among the states participating in the study, through the Plátano Clinical Research Center, which has already begun to register interested parties.

Currently, more potent flu vaccines for the elderly are only available in the private sector, which restricts access for a large part of the population. The study with the new Butantan vaccine seeks to change this reality.

The research will assess whether Butantan's new adjuvanted vaccine is equivalent to or superior to the high-concentration vaccine marketed in private clinics. If the results confirm its effectiveness, the impact could be direct on public health.

…