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Public trial

Effects of hormone treatment in transsexual women and HIV-positive transvestites or at high risk of HIV infection

Date of registration: 03/26/2019 ^(mm/dd/yyyy)
Last approval date : 03/26/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Observational

Influence of lemon on the inflammatory activity of healthy women during menstruation

Date of registration: 03/25/2019 ^(mm/dd/yyyy)
Last approval date : 03/25/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Comparison of the effects of oral and intramuscular use of corticosteroids on pain, swelling and mouth opening and closing movements after extraction of the wisdom tooth

Date of registration: 03/25/2019 ^(mm/dd/yyyy)
Last approval date : 03/25/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Change in effort capacity and life quality after pulmonary reabilitation in pre lung trasplantation patients /Clinics Hospital of Universidade Federal de Minas Gerais

Date of registration: 03/25/2019 ^(mm/dd/yyyy)
Last approval date : 03/25/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

The autonomic balance in asthmatic children

Date of registration: 03/21/2019 ^(mm/dd/yyyy)
Last approval date : 03/21/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Laboratory and clinical evaluation of a resin restorative system without bisphenol a used for gluing orthodontic brackets

Date of registration: 03/21/2019 ^(mm/dd/yyyy)
Last approval date : 03/21/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Clinical Evaluation of Ceramic Restorations Glued to the Tooth

Date of registration: 03/21/2019 ^(mm/dd/yyyy)
Last approval date : 03/21/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Use of Virus-Specific Lymphocytes for Treatment of Patients with Low Immunity After Bone Marrow Transplantation

Date of registration: 03/20/2019 ^(mm/dd/yyyy)
Last approval date : 03/21/2019 ^(mm/dd/yyyy)
Last revision: 2

Study type:

Interventional

Pilates Method Versus Stretching in neuromuscular variables

Date of registration: 03/20/2019 ^(mm/dd/yyyy)
Last approval date : 03/20/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Effects of baru oil supplementation on body composition, inflammation, oxidative stress, lipid profile and blood fatty acids of hemodialysis patients

Date of registration: 03/20/2019 ^(mm/dd/yyyy)
Last approval date : 03/20/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Temporomandibular joint disorder: structural changes, function and causal factors

Date of registration: 03/20/2019 ^(mm/dd/yyyy)
Last approval date : 03/20/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Observational

Clinical evaluation of restorations using a new resin composite

Date of registration: 03/20/2019 ^(mm/dd/yyyy)
Last approval date : 03/20/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Use of troat pack in orthognathic surgery

Date of registration: 03/19/2019 ^(mm/dd/yyyy)
Last approval date : 03/19/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Use of Topical Anesthetic Cream for pain relief caused by the injection of Spinal Anesthesia in elective cesarean sections

Date of registration: 03/15/2019 ^(mm/dd/yyyy)
Last approval date : 03/15/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Alteration of kidney function in patients undergoing video surgery

Date of registration: 03/15/2019 ^(mm/dd/yyyy)
Last approval date : 03/15/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Motor development in children exposed to social risks in the family

Date of registration: 03/15/2019 ^(mm/dd/yyyy)
Last approval date : 03/15/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Observational

Effect of acute consumption of juçara juice in damage indicators caused by free radicals and inflammation before and after exercise and the relation with depressive symptoms and anxiety

Date of registration: 03/15/2019 ^(mm/dd/yyyy)
Last approval date : 03/15/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

To determine the oxygen saturation levels (SaO2) of the pulp of permanent molars of adult patients who will need to perform direct pulp capping due to pulpal caries exposure, through pulse oximeter evaluation before and after treatment with MTA or glass bioactive 45S5.

Date of registration: 03/15/2019 ^(mm/dd/yyyy)
Last approval date : 03/15/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

Effectiveness Evaluation of a Comprehensive Care Model in Oral Health for Pregnant Women in Gestational Outcomes: Randomized Clinical Trial

Date of registration: 03/14/2019 ^(mm/dd/yyyy)
Last approval date : 03/14/2019 ^(mm/dd/yyyy)
Last revision: 1

Study type:

Interventional

The effects of electrical stimulation on the scalp in painful shoulder post-stroke rehabilitation.

Date of registration: 10/11/2017 ^(mm/dd/yyyy)
Last approval date : 03/14/2019 ^(mm/dd/yyyy)
Last revision: 2

Study type:

Interventional

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News

10/03/2025

Potential Alzheimer’s treatment, trontinemab, hits the news – how does it work and is it available?

10/03/2025 | Emma Taylor | Alzheimer's Research UK

https://www.alzheimersresearchuk.org/news/potential-alzheimers-treatment-trontinemab-hits-the-news-how-does-it-work-and-is-it-available/

Three years ago, the results of a trial for lecanemab marked a turning point. They showed for the first time that Alzheimer’s disease can be slowed by medication. Not long after, another drug called donanemab followed with similar results.

In 2025, there are almost 140 drugs in clinical trials across the world. More than ever, there is hope that real change is coming – hope that people who develop dementia in the future won’t face the same realities as they sadly do today.

Some of that hope is resting on the results of what could be the second generation of Alzheimer’s treatments. In particular, a new drug called trontinemab has recently hit the headlines following some promising early results. But we won’t know for sure how well the drug works until at least 2028, when the current trial is due to end. Read on to find out if you could help scientists to find out whether this drug could be life-changing for people affected by dementia.

What is trontinemab?
Trontinemab is a potential new Alzheimer’s drug made by the pharmaceutical company Roche. It is still in development, with a trial due to start in autumn 2025.

Data from early phase trials suggests that this drug may target an underlying process in Alzheimer’s quickly and effectively.

However, we don’t yet know whether the drug will slow down symptoms getting worse. Until these data are released, we cannot say whether this drug could be effective in the treatment of Alzheimer’s disease.

How does trontinemab…

10/03/2025
Innovation in healthcare roundup: HCA Healthcare, the Allergy Centre of Excellence, Fujifilm and Optegra

10/03/2025 | Adrian Murdoch | Heathcare Today

https://healthcaretoday.com/article/innovation-in-healthcare-roundup-hca-healthcare-the-allergy-centre-of-excellence-fujifilm-and-optegra

The latest innovations in healthcare, including tumour-infiltrating lymphocyte therapy, allergies, cancer support and drop-free cataract treatment.
HCA Healthcare trials tumour-infiltrating lymphocyte therapy
US-owned private hospital operator HCA Healthcare will treat a metastatic lung cancer patient with tumour-infiltrating lymphocyte (TIL) therapy for the first time as part of a clinical trial at its research arm, Sarah Cannon Research Institute UK.

TIL therapy leverages the body’s own immune cells called tumour-infiltrating lymphocytes, which are naturally present within tumours and trained to target cancer cells. In February 2024, the Food and Drug Administration (FDA) approved TIL therapy as the first cellular therapy to treat solid tumours, initially for melanoma treatment under the name Lifileucel (Amtagvi).

At Sarah Cannon Research Institute UK, clinical trials are now exploring TIL therapy’s efficacy in advanced and metastatic non-small-cell lung cancer. The patient was referred from the NHS for participation in this groundbreaking clinical trial.

“TIL therapy represents a potential new treatment option for patients whose advanced cancer has become resistant to other therapies,” said Anja Williams, consultant medical oncologist at Sarah Cannon Research Institute UK. “By using the patient’s own immune cells that are already trained to target their specific cancer, we’re essentially harnessing and enhancing the power of their immune system to target the disease,” she continued.

First…

10/03/2025
How Government Shutdowns Set Back Clinical Trials

10/03/2025 | Denise N. Bronner | Clinical Leader

https://www.clinicalleader.com/doc/how-government-shutdowns-set-back-clinical-trials-0001

When the federal government shuts down, news coverage tends to spotlight furloughed workers, frozen paychecks, or the political drama playing out in Washington. What gets less attention is how these lapses stall the engine of scientific progress. For clinical research, even a brief shutdown can trigger cascading consequences: disrupted operations, wavering patient participation, delayed approvals, and setbacks for urgently needed therapeutics.

Clinical research thrives on continuity. It is built on tightly orchestrated timelines, fragile patient trust, and a steady flow of regulatory and financial resources. When that continuity is interrupted, the ripple effects extend far beyond missed deadlines. They reach the lives of patients who depend on trials for care and the future of therapies waiting to move from pipeline to practice.

Regulatory Bottlenecks & Uncertainty
The FDA sits at the center of clinical research, reviewing new drug applications, monitoring safety, and ensuring compliance. A shutdown leaves the agency with only a skeleton crew. Historically, about one-third of FDA staff have been furloughed during extended shutdowns, forcing the Agency to pause most routine operations. New drug and device submissions may be accepted, but reviews stall. Site inspections and audits, critical for moving programs forward, are postponed. And sponsors often find their regulatory queries met with silence.

These delays may seem procedural, but they create real-world consequences. A biotech preparing to launch a pivotal trial might suddenly find its timeline upended. A CRO monitoring multiple sites may have to cancel visits, raising questions…

10/01/2025
Enactment of Law No. 14,874 ushers in a new era of clinical research

09/29/2025 | Fernando de Rezende Francisco | Medicina S/A

https://medicinasa.com.br/sancao-lei-14-874-2024/

Brazil has begun a new chapter in Clinical Research with the enactment of Law No. 14,874/2024, which establishes a robust and modern regulatory framework in line with international best practices. More than just updating standards, the law creates conditions to expand the population's access to studies that bring innovation, new therapies, and a better quality of life.

Although the legislative process took almost a decade, the most recent stage of this process was marked by the leading role played by the Ministry of Health, through the Secretariat of Science, Technology, Innovation, and Health Complex (SECTICS) and the Department of Science and Technology (DECIT). In recent months, these areas have taken the lead on the agenda, competently and dialogically conducting the process that will culminate in the beginning of the regulation of the law and the reorganization of the ethical research system.

Despite its enormous potential, Brazil participates in just over 1% of global clinical studies, according to ClinicalTrials.gov. This means less investment, less access to cutting-edge technologies, and fewer opportunities for patients. Law No. 14,874/2024 paves the way for changing this scenario, and the recent actions of the Ministry of Health are decisive in consolidating these transformations.

The movement to draft a law for this area gained momentum in 2014 when Afonso Celso Haas, a businessman from Rio Grande do Sul diagnosed with advanced lung cancer, found a chance to prolong his life in a clinical trial. The experimental treatment not only gave him five additional years with his family, but also turned him into a symbol of the fight for the modernization of the sector.

Inspired by his story, doctors, lawmakers, organizations, and civil society…

10/01/2025
Law 14.874/24: a new perspective for clinical research in Brazil

10/01/2025 | Eurico Bitencourt Neto, Brunello Stancioli | Jota

https://www.jota.info/opiniao-e-analise/artigos/lei-14-874-24-uma-nova-perspectiva-para-a-pesquisa-clinica-no-brasil

Legislation is welcome and represents a bioethical and administrative milestone for Brazilian research

Improvements in the health, well-being, and productivity of contemporary societies are largely linked to advances in biomedical research and the improvements they bring to collective and individual health. In an era marked by exponential production of information and knowledge and, at the same time, by growing uncertainty and risk, biomedical sciences play a central role as a tool that saves lives and prevents disease in a world that still grapples with profound inequalities, thus serving as an important instrument of social justice.

In this context of undeniable relevance, the progress of biomedical research involves a double ethical challenge. On the one hand, preventing or hindering scientific research means hindering prophylaxis, cure, and prevention for countless diseases, hindering the achievement of better health conditions and adequate care for those facing various causes of suffering. On the other hand, clinical research involves the participation of volunteers who agree to subject themselves to certain risks in order for scientific progress to be achieved, which requires a protection system that ensures the preservation of their fundamental rights of personality.

Ensuring the ethics of research and the safety and interests of research participants is fundamental in this process, as they are the key to the tests that culminate in scientific advancement. However, until last year, Brazil offered very fragile legal guarantees to research participants.

Research ethics standards in Brazil…

Total de Ensaios Clínicos 16964.

Existem 8361 ensaios clínicos registrados.

Existem 4703 ensaios clínicos recrutando.

Existem 247 ensaios clínicos em análise.

Existem 5769 ensaios clínicos em rascunho.

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